Een belangrijk speerpunt binnen de acute interne geneeskunde is de wetenschap, waarbij men zorg draagt voor het initiëren van wetenschappelijk onderzoek naar acute aandoeningen en organisatie van acute zorg.Op dit moment wordt er op verschillende vlakken wetenschappelijk onderzoek verricht. Hieronder vindt u een selectie van recente publicaties:

  • ABCDE-systematiek en CRM
  • Flashmob research
  • Gastro-intestinale bloedingen op spoedeisende hulp
  • Geriatrie op de spoedeisende hulp:
  • Intoxicaties/farmacologie
  • Organisatie spoedeisende hulp
  • Risico-stratificatie spoedeisende zorg
  • Sepsis
  • Serious gaming in acute geneeskunde

Overzicht publicaties

ABCDE-systematiek en CRM:
Olgers TJ, Dijkstra RS, Drost-de Klerck AM, Ter Maaten JC. The ABCDE primary assessment in the emergency department in medically ill patients: an observational pilot study. Neth J Med. 2017 Apr;75(3):106-111.

Flashmob research:
Alsma J, Jan LCM van Saase, Prabath WB Nanayakkara, WEM Ineke Schouten, Anique Baten, Martijn P. Bauer, Frits Holleman, Jack JM. Ligtenberg, Patricia M. Stassen, Karin A. Kaasjager, Harm Haak, Frank H. Bosch,Stephanie CE. Schuit on behalf of the Famous Study GroupThe Power of Flash Mob Research – Conducting a nationwide observational clinical study on Capillary Refill Time in a single day Chest. 2016 Dec 6. pii: S0012-3692(16)62563-1. doi:

Gastro-intestinale bloedingen op spoedeisende hulp:
M Aquarius, FG Smeets, HW Konijn, PM Stassen, ET Keulen, CT van Deursen, AA Masclee, YC Keulemans YC – Prospective multicenter validation of the Glasgow Blatchford bleeding score in the management of patients with upper gastrointestinal hemorrhage presenting at an emergency department. Eur J Gastroenterol Hepatol. 2015 Sep;27(9):1011-6

PM Stassen, YCA Keulemans, M Aquarius – Bloedtransfusie bij de acuut bloedende patiënt: te veel te vroeg of te weinig te laat? Nederlands Tijdschrift voor Geneeskunde 2013;157:A6205

Geriatrie op de spoedeisende hulp:
Van de Meeberg EK, Festen S, Kwant M, Georg RR, Izaks GJ, Ter Maaten JC. Improved detection of delirium, implementation and validation of the CAM-ICU in elderly Emergency Department patients. Eur J Emerg Med. 2016 Feb 18

Quax RA, Alsma J. On calcium channel antagonist poisoning: towards evidence-based decision making in poisoned patients. Neth J Med. 2016 Feb;74(2):58-9.

M Cobussen, JML de Kort, R Dennert, S Lowe, PM Stassen – No increased risk of acute kidney injury (AKI) after a single dose of gentamicin in the emergency department: a retrospective cohort analysis. Infectious diseases, 2015 Nov 15:1-7 (Epub)

DA Joosen, PM Stassen – Acute dyspnea caused by hypocalcemia-related laryngospasm. Journal of  Emergency Medicine 2015, Jan;48(1):29-30 Lameijer H, Azizi N, Ligtenberg JJ, Ter Maaten JC. Ventricular Tachycardia After Naloxone Administration: a Drug Related Complication? Case Report and Literature Review. Drug Saf Case Rep. 2014 Dec;1(1):2. Review.

Ligtenberg JJ, Olgers TJ, van de Meeberg EK, ter Maaten JC. Re: MDMA-associated cerebral edema resembling psychogenic polydipsia? J Emerg Med. 2015 Jan;48(1):81-2. doi: 10.1016/j.jemermed.2013.08.148. Epub 2014 Oct 1.

Bens BW, ter Maaten JC, Ligtenberg JJ. [Carbon monoxide poisoning after smoking from a water pipe]. Ned Tijdschr Geneeskd. 2013;157(29):A6201.

von Martels JZ, Van de Meeberg EK, Holman M, Ligtenberg JJ, Ter Maaten JC. Pseudolithiasis after recent use of ceftriaxone: an unexpected diagnosis in a child with abdominal pain. Am J Emerg Med. 2013 Aug;31(8):1294.e5-6. doi: 10.1016/j.ajem.2013.04.022. Epub 2013 Jul 1. van der Have M, Dekker D, Theunissen EMJ, Snijders C, Kaasjager KAH. It is all about the form – adrenaline in anaphylaxis: intravenous or intramuscular administration? Ned Tijdschr Geneeskd. 2017;161(0):D1089.

Organisatie Spoed eisende hulp:

Kremers MNT, Nanayakkara PWB, Levi M, Bell D, Haak HR “Strengths and weaknesses of the acute care systems in the United Kingdom and the Netherlands: what can we learn from each other?“. BMC Emergency Medicine, 2019 Jul 26;19(1):40. doi: 10.1186/s12873-019-0257-y

SHA Brouns, PM Stassen, SLE Lambooij, J Dieleman, ITP Vanderfeesten, HR Haak – Organizational Factors induce Prolonged Emergency Department Length of Stay in Elderly Patients. Plos One 2015 Aug 12;10(8):e0135066

F Magdelijns, D Gulikers, R Ramaekers, E Pijpers, R-P Koopmans, PM Stassen – The emergency department: a place to monitor complications within and beyond the internal medicine practice. Netherlands Journal of Medicine 2013 Jan;71(1):44-9

Stassen PM. Acute medical units, providing continuity of care may be the next focus. Eur J Intern Med. 2017 Apr;39:e12. doi: 10.1016/j.ejim.2017.01.005. Epub 2017 Jan 10.

F Magdelijns, E Pijpers, R ten Broeke, R Rouhl, PM Stassen – Acute hospital admissions due to a health care related adverse event: experiences from 5 clinical specialties. JAMDA 2015 Aug 6

Risico-stratificatie spoedeisende zorg:

Uffen, J.W., Oomen, P., Regt, M. et al. The prognostic value of red blood cell distribution width in patients with suspected infection in the emergency department. BMC Emerg Med19, 76 (2019) doi:10.1186/s12873-019-0293-7

PM Stassen en E Pijpers – Risico-stratificatie op de SEH: een must. Nederlands Tijdschrift voor Geneeskunde 2012;156(40):A5274

MJM Hilderink, AA Roest, MAW Hermans, YC Keulemans, CDA Stehouwer, PM Stassen – Validity and feasibility of risk stratification scoring systems to predict 28-day mortality of septic patients in a Dutch emergency departmentEuropean Journal of Emergency Medicine(EPub) aug, 2014

van den Nouland DP, Brouwers MC, Stassen PM. Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department. BMJ Open. 2017 Jan 30;7(1):e011450.

FJH Magdelijns, LSchepers, E Pijpers, CDA Stehouwer and PM Stassen – The survival of patients admitted because of health-care-related adverse events is similar to that after admission for other reasons. European Journal of Internal Medicine 2015, Mar;26(2):146-7

Oord M, Olgers TJ, Doff-Holman M, Harms MP, Ligtenberg JJ, Ter Maaten JC. Ultrasound and NICOM in the assessment of fluid responsiveness in patients with mild sepsis in the emergency department: a pilot study. BMJ Open. 2017 Jan 27;7(1):e013465. doi: 10.1136/bmjopen-2016-013465.

Quinten VM1, van Meurs M, Ter Maaten JC, Ligtenberg JJ. Biomarkers or Clinical Observations to Identify (Outcome of) Emergency Department Patients With Infection? Shock. 2016 Jul;46(1):108. doi: 10.1097/SHK.0000000000000582.

Serious gaming in acute geneeskunde:
Dankbaar ME, Richters O, Kalkman CJ, Prins G, Ten Cate OT, van Merrienboer JJ, Schuit SC. Comparative effectiveness of a serious game and an e-module to support patient safety knowledge and awareness. BMC Med Educ. 2017 Feb 2;17(1):30. doi: 10.1186/s12909-016-0836-5.

Dankbaar ME, Roozeboom MB, Oprins EA, Rutten F, van Merrienboer JJ, van Saase JL, Schuit SC. Preparing Residents Effectively in Emergency Skills Training With a Serious Game. Simul Healthc. 2017 Feb;12(1):9-16.

Dankbaar ME, Alsma J, Jansen EE, van Merrienboer JJ, van Saase JL, Schuit SC. An experimental study on the effects of a simulation game on students’ clinical cognitive skills and motivation. Adv Health Sci Educ Theory Pract. 2016 Aug;21(3):505-21. doi: 10.1007/s10459-015-9641-x. Epub 2015 Oct 3.

AA Roest, J Tegtmeier, JJ Heyligen, J Duijst, A Peeters, HF Borggreve, AML Oude Lashof, CDA Stehouwer, PM Stassen – Risk stratification by AbbMEDS and CURB-65 in relation to treatment and disposition of the septic patient at the emergency department. BMC Emergency Medicine 2015 BMC Oct 13;15:29

AA Roest, J Stoffers, E Pijpers, PM Stassen – Ambulance patients with non-documented sepsis have a high mortality risk. European Journal of Emergency Medicine 2015 Jul 31

M Cobussen, V Hira, JML de Kort, D Posthouwer, PM Stassen, MB Haeseker – Gentamicin is frequently underdosed in patients with sepsis in the emergency department. Netherlands Journal of Medicine 2015 Nov;73(9):443-444

M Groenewoudt, AA Roest, FMM Leijten, PM Stassen – Sepsis patients in the ambulance: a seriously ill population.European Journal of Emergency Medicine 2014 Oct;21(5):330-5tevens voordracht voor GGD-Zuid-Limburg, september 2013

Ligtenberg JJ, Ter Maaten JC, Zijlstra JG. Back to basics in sepsis treatment: critically ill patients need intensive care. Crit Care. 2014 Jan 31;18(1):405. doi: 10.1186/cc13714.

Ligtenberg JJ, Azizi N, Glatman K, Ter Maaten JC, Zijlstra JG. Severe sepsis: stay and play or scoop and run? Am J Respir Crit Care Med. 2013 Aug 15;188(4):513.

Ter Avest E, de Jong M, Brűmmer I, Wietasch GJ, Ter Maaten JC.Outcome predictors of uncomplicated sepsis. Int J Emerg Med. 2013 Apr 8;6(1):9. doi: 10.1186/1865-1380-6-9

Quinten VM, van Meurs M, Wolffensperger AE, Ter Maaten JC, Ligtenberg JJM. Sepsis patients in the emergency department: stratification using the Clinical Impression Score, Predisposition, Infection, Response and Organ dysfunction score or quick Sequential Organ Failure Assessment score? Eur J Emerg Med. 2017 May 8. doi: 10.1097/MEJ.0000000000000460.

Quinten VM, van Meurs M, Ter Maaten JC, Ligtenberg JJ. Trends in vital signs and routine biomarkers in patients with sepsis during resuscitation in the emergency department: a prospective observational pilot study. BMJ Open. 2016 May 25;6(5):e009718. doi: 10.1136/bmjopen-2015-009718.